Constitutively activated prosurvival pathways render cancer cells addicted to their effects. Consequently they turn out to be the Achilles’ heels whose inhibition can be exploited in anticancer therapy. Primary effusion lymphomas (PELs) are very aggressive non-Hodgkin’s B cell lymphomas, whose pathogenesis is strictly linked to Kaposi’s sarcoma herpesvirus (KSHV) infection. Here we summarized previous studies from our and other laboratories exploring the cytotoxic effect of drugs inhibiting the main prosurvival pathways activated in PEL cells. Moreover, the immunogenicity of cell death, in terms of dendritic cell (DC) activation and their potential side effect on DCs, is discussed.

Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future / Granato, Marisa; Santarelli, Roberta; Gonnella, Roberta; Farina, Antonella; Trivedi, Pankaj; Faggioni, Alberto; Cirone, Mara. - In: BIOMED RESEARCH INTERNATIONAL. - ISSN 2314-6141. - (2015). [10.1155/2015/104912]

Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future

GRANATO, Marisa;SANTARELLI, Roberta;GONNELLA, ROBERTA;FARINA, Antonella;TRIVEDI, PANKAJ;FAGGIONI, Alberto;CIRONE, Mara
2015

Abstract

Constitutively activated prosurvival pathways render cancer cells addicted to their effects. Consequently they turn out to be the Achilles’ heels whose inhibition can be exploited in anticancer therapy. Primary effusion lymphomas (PELs) are very aggressive non-Hodgkin’s B cell lymphomas, whose pathogenesis is strictly linked to Kaposi’s sarcoma herpesvirus (KSHV) infection. Here we summarized previous studies from our and other laboratories exploring the cytotoxic effect of drugs inhibiting the main prosurvival pathways activated in PEL cells. Moreover, the immunogenicity of cell death, in terms of dendritic cell (DC) activation and their potential side effect on DCs, is discussed.
2015
heat shock protein; immunoglobulin enhancer binding protein; antivirus agent
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future / Granato, Marisa; Santarelli, Roberta; Gonnella, Roberta; Farina, Antonella; Trivedi, Pankaj; Faggioni, Alberto; Cirone, Mara. - In: BIOMED RESEARCH INTERNATIONAL. - ISSN 2314-6141. - (2015). [10.1155/2015/104912]
File allegati a questo prodotto
File Dimensione Formato  
Granato_Targeting-prosurvival_2015.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 2.56 MB
Formato Adobe PDF
2.56 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/675270
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 11
social impact